Simon J Lees, PhD

Faculty of Medicine, Lakehead University

The IL-6 paradox in the development of insulin resistance

Paradoxically, elevated IL-6 is associated with insulin resistance and type 2 diabetes, while at the same time strong evidence supports the notion that IL-6 may facilitate improved insulin signaling as a result of physical activity. The proposed research will determine the role of IL-6 in response to physical activity in the prevention of type 2 diabetes. The findings will be critical to our understanding of the fundamental mechanisms leading to the development of insulin resistance and ultimately type 2 diabetes. Moreover, these results will provide valuable insight into the development of future therapeutic interventions.

Banting Research Foundation
Founded in 1925 by supporters of Frederick Banting,
1923 Nobel laureate for the discovery of insulin


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