Physics Department, Ryerson University
Surface-enhanced Raman fiber sensor for endoscopic early detection of tumor-related biomolecules in gastroenterology
The goal of the project is development of surface-enhanced Raman spectroscopy fiber probes for high sensitive and rapid non-invasive diagnostics including malignancy detection. Optical sampling of biological molecules can detect specific Raman “fingerprints” including cancer “signatures” with high accuracy. Traditional Raman spectroscopy has been successfully applied to cancer diagnostics with over 97% accuracy; however, this method is associated with long signal collection time, which makes it impractical for clinical diagnostics in vivo.
Meeting clinical needs and employing the recent advances in nano-metamaterial technologies is expected to provide molecular detection with high accuracy within fractions of a second.