Craig Bailey, PhD

Department of Biomedical Sciences, University of Guelph

Nicotinic receptor signaling in a mouse model of Fetal Alcohol Spectrum Disorder

Neurons

Neurons

Chronic prenatal exposure to alcohol can produce a spectrum of adverse effects known collectively as Fetal Alcohol Spectrum Disorder (FASD). Although deficits in attention rank among the most common and persistent components of FASD, mechanisms underlying this behavioural outcome are not known. This project aims to determine mechanisms by which exposure to alcohol during development alters the brain’s attention systems.

Craig Bailey, recipient of a 2013 Banting Research Foundation grant

Craig Bailey, recipient of a 2013 Banting Research Foundation grant

We will focus on the nicotinic acetylcholine neurotransmitter system within the prefrontal cortex, because it is important for normal attention behavior and can be modulated by short- and long-term exposure to alcohol. The long-term goal of this research is to identify appropriate therapeutic interventions to mitigate attention deficits in FASD.

Banting Research Foundation
Founded in 1925 by supporters of Frederick Banting,
1923 Nobel laureate for the discovery of insulin


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