David Chatenet, PhD

Centre INRS–Institut Armand-Frappier

Design and synthesis of peptide inhibitors of PqsE as novel antibacterial therapeutics

David Chatenet with lab members

David Chatenet, recipient of a 2013 Banting Research Foundation grant, with lab colleagues at Centre INRS – Institut Armand-Frappier. (Photo: Christian Fleury)

Pseudomonas aeruginosa (Pa), a prevalent opportunistic human pathogen responsible for morbidity and mortality among individuals suffering from cystic fibrosis, is notorious for its high resistance to antibiotic treatments.

As recently demonstrated, cell-to-cell signaling regulated by the PqsE enzyme plays a central role in the control of the pathogenicity of Pa by modulating the expression of virulence-related functions. As such, PqsE represents a potential target for therapeutic intervention. The present proposal aimed to design specific inhibitors of this enzyme through a combinatorial chemistry approach and to evaluate their potential as new antibacterial agents.

Banting Research Foundation
Founded in 1925 by supporters of Frederick Banting,
1923 Nobel laureate for the discovery of insulin


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