26 August 2016

Moriarty lab shows how Lyme disease bacteria spread through the body

Tara Moriarty PhD and PhD student Rhodaba Ebady at the University of Toronto have developed an imaging system that is able to show how bacterial cells move through blood vessels to infect other parts of the body. Using the bacteria that causes Lyme disease, Borrelia burgdorferi, they showed how bacterial cells attach themselves to the inner surface of blood vessels with tether-like structures, grabbing and releasing to move themselves along without being swept away by the forces of blood flow. Knowing the mechanism of this movement is a critical step in the development of therapeutics to treat Lyme disease and other similar infections. READ THE WHOLE STORY »

27 July 2016

2016 Discovery Award Recipients

Congratulations to the Banting Research Foundation 2016 Discovery Award recipients. Six grants were funded in the 2016 competition out of 50 applications. The successful Discovery Award recipients are:

26 July 2016

Jeanette Boudreau, PhD

Department of Microbiology and Immunology, Dalhousie University

Directing natural killer cell cytotoxicity to the tumour’s susceptibilities

Boudreau_lab
Natural killer (NK) cells are white blood cells that kill tumours. The potential of each NK cell to kill tumours is counterbalanced by its ability to be inhibited by healthy cells through its inhibitory receptors. Dr Boudreau aims to tip the balance in favour of NK killing, rather than inhibition, when they encounter a tumour cell. READ THE WHOLE STORY »

26 July 2016

Christopher Dennison, PhD

Department of Mechanical Engineering, University of Alberta

Impact severity metric for focal head and diffuse brain injury

(Photo: Richard Siemens)

(Photo: Richard Siemens)

Whether or not today’s helmets protect the wearer from mild diffuse brain injuries, sometimes referred to as concussions, is the topic of intense debate. One of the primary venues for this debate is in the helmet standards and certification community. READ THE WHOLE STORY »

26 July 2016

Jeffrey Gagnon, PhD

Department of Biology, Laurentian University

Investigating the role of H2S in the regulation of ghrelin secretion

Jeffrey Gagnon with student in lab

Jeffrey Gagnon with student in lab


Ghrelin, a hormone produced in the endocrine cells of the stomach, regulates several aspects of metabolic health, including appetite and energy storage. Recently, meals high in the amino acid cysteine have been shown to reduce ghrelin secretion. Foods rich in this amino acid also lead to increased production of the bioactive gas molecule hydrogen sulfide (H2S). H2S has been shown to regulate many aspects of health, including inflammation, cardiovascular health, and endocrine control. Dr Gagnon believes that ghrelin cells can metabolize cysteine to produce their own H2S, and that this H2S reduces ghrelin secretion and reduces appetite. He will first demonstrate how H2S and its precursor amino acid L-cysteine can regulate ghrelin secretion using several ghrelin producing cell models. He will then examine how this amino acid, and its gas metabolite, can suppress food intake through the suppression of ghrelin. This work will provide important information on how ghrelin and appetite is regulated by H2S and may lead to new strategies in weight management.

26 July 2016

Kaitlyn McLachlan, PhD

Department of Psychology, University of Guelph

Evaluating novel neurobiomarkers in the identification of adults with FASD using portable eye tracking and EEG technology

Individuals with fetal alcohol spectrum disorder (FASD) are overrepresented in the criminal justice system. There is an urgent need to identify neurobiomarkers of FASD and individuals at risk in order to reduce recidivism and the resulting high social, health, and economic costs. Novel use of neurotechnologies, including portable eye movement control tracking and EEG, may offer a window into the brain and aid in the identification of patterns of deficits in offenders with FASD. READ THE WHOLE STORY »

26 July 2016

Noam Miller, PhD

Department of Psychology, Wilfrid Laurier University

Exploring neural mechanisms of social behavior using zebrafish (Danio rerio)

(l to r) Ramy Ayoub, Mackenzie Schultz, Noam Miller, Chelsey Damphousse

(l to r) Ramy Ayoub, Mackenzie Schultz, Noam Miller, Chelsey Damphousse

This research study uses zebrafish, a small freshwater species of fish commonly used in genetic and developmental research, to explore the mechanisms of social behavior. Zebrafish spend the majority of their time in groups and have complex social interactions, including learning from each other, making collective decisions about where to search for food, and communicating about the presence of predators. READ THE WHOLE STORY »

26 July 2016

Roxane Paulin, PhD

Department of Medicine, Université Laval

Targeting ErbB2 by TAK-165 reverses pulmonary hypertension in vitro and in vivo

Roxane Paulin and her Groupe de Recherche en Hypertension Pulmonaire, Université Laval

Roxane Paulin and her Groupe de Recherche en Hypertension Pulmonaire, Université Laval

In pulmonary hypertension (high blood pressure in the lungs), cells forming the walls of arteries in the lungs proliferate like cancer cells, narrowing the arteries and making it difficult for blood to pass through. There is also evidence of inflammation, similar to that in infections, and evidence of insulin resistance, as in diabetes. READ THE WHOLE STORY »

16 May 2016

Janet Rossant, PhD, invested to the Order of Canada

Governor General David Johnston invests Dr Janet Rossant as a Companion of the Order of Canada. (Photo: Adrian Wyld /Canadian Press)

Governor General David Johnston invests Dr Janet Rossant as a Companion of the Order of Canada. (Photo: Adrian Wyld /Canadian Press)


Dr Janet Rossant was invested into the Order of Canada in a ceremony at Rideau Hall on May 13, 2016. She was appointed in May 2015 to the rank of Companion of the Order of Canada, the highest level within the Order, for advancing the global understanding of embryo development and stem cell biology, and for her national and international leadership in health science.
Earlier in 2016, Dr Rossant was awarded the 2016 Henry G. Friesen International Prize in Health Research, and in 2015, received the prestigious Canada Gairdner Wightman Award for her outstanding scientific contributions to developmental biology and for her exceptional international leadership in stem cell biology and policy-making, and in advancing research programs for children’s illnesses.
Dr Rossant is internationally renowned as a developmental biologist, known for her studies of the genes that control embryonic development. Originally from the UK, she came to Canada in 1977 to assume a faculty position at Brock University. She moved to the University of Toronto in 1985, at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital and then at the Hospital for Sick Children, where she was Chief of Research.
While an assistant professor at Brock University in 1983, Dr Rossant received a grant from the Banting Research Foundation for her early research in developmental biology. She says, “the early support of the Banting Research Foundation was very helpful in setting my course towards the Gairdner Wightman Award.”

24 August 2015

Grant Recipients 2015

In 2015, the following early-career researchers received Banting Research Foundation Discovery Awards:

Jeffrey Chen, PhD, University of Saskatchewan
Towards a next generation of superior BCG tuberculosis vaccines

Jeremy Hirota, PhD, University of British Columbia
A 3D-printed human airway model for studying respiratory mucosal immune responses

Petra Kienesberger, PhD, Dalhousie University
Role of the adipokine autotaxin in obesity-associated insulin resistance

Morgan Langille, PhD, Dalhousie University
Design and implementation of a human microbiome interaction database

Joon Lee, PhD, University of Waterloo
Personalized predictive analytics based on electronic medical data and patient similarity metrics

Catherine Martel, PhD, Université de Montréal
Lymphatic vessel function in atherosclerosis

Michael Suits, PhD, Wilfrid Laurier University
Protein structure-function relationships in periodontal disease

21 August 2015

Jeffrey Chen, PhD

VIDO-InterVac, University of Saskatchewan

Towards a next generation of superior BCG tuberculosis vaccines

(Photo: Trenna Brusky, VIDO InterVac)

(Photo: Trenna Brusky, VIDO InterVac)

Tuberculosis is a serious global health problem, with one-third of the world’s population having been infected by the infectious agent, Mycobacterium tuberculosis. The only available tuberculosis vaccine, live M. bovis BCG vaccine, has an excellent record in protecting infants, but works poorly in adolescents and adults. Therefore, better tuberculosis vaccines are urgently required. READ THE WHOLE STORY »

21 August 2015

Jeremy Hirota, PhD

Department of Medicine, University of British Columbia

A 3D-printed human airway model for studying respiratory mucosal immune responses

Jeremy Hirota

Jeremy Hirota

Exposure to allergens and air pollutants in the air we breathe can lead to “lung attacks” in individuals with lung diseases, but it is unclear how this happens and what we can do to stop it. Dr Hirota’s research group studies how exposure to inhaled allergens and air pollution causes irritation and swelling (inflammation) in the lungs, leading to difficulty breathing, and how this causes lung attacks. READ THE WHOLE STORY »

21 August 2015

Petra Kienesberger, PhD

Department of Biochemistry and Molecular Biology, Dalhousie University

Role of the adipokine autotaxin in obesity-associated insulin resistance

Kienesberger_cropped 300w
Insulin resistance, a major complication of obesity, is a condition where tissues such as skeletal muscle become unresponsive to the blood sugar-lowering hormone insulin. Insulin resistance can lead to type 2 diabetes, which is associated with a shorter life expectancy. Fat tissue releases proteins that influence insulin resistance in obesity. One of these recently identified fat-derived proteins is autotaxin. READ THE WHOLE STORY »

21 August 2015

Morgan Langille, PhD

Department of Pharmacology, Dalhousie University

Design and implementation of a human microbiome interaction database

It is becoming increasingly apparent that the microbes living on and in our bodies, called the human microbiome, are important for human health. These microbes help with the digestion of food, defend against unwanted pathogens, stimulate and keep our immune systems in check, and synthesize essential vitamins. In addition, changes in the microbiome have been linked to various diseases and health concerns such as obesity, irritable bowel disease, diabetes, colon cancer, and various autoimmune diseases. READ THE WHOLE STORY »

21 August 2015

Joon Lee, PhD

School of Public Health and Health Systems, University of Waterloo

Personalized predictive analytics based on electronic medical data and patient similarity metrics

A regular group meeting of the Health Data Science Lab at the University of Waterloo

A regular group meeting of the Health Data Science Lab at the University of Waterloo


As hospitals and doctors’ offices in Canada rapidly adopt electronic medical records (EMRs), the enormous clinical value of ever-increasing EMR data is receiving the spotlight. In particular, massive EMR data can facilitate personalized medical treatment through identification and analysis of past patients who are similar to a current patient. READ THE WHOLE STORY »

21 August 2015

Catherine Martel, PhD

Department of Medicine, Université de Montréal/ Montreal Heart Institute Research Centre

Lymphatic vessel function in atherosclerosis

Martel lab group, left to right, François Dallaire, Andreea Milasan, Catherine Martel (Photo: Jonathan B. Béland)

Martel lab group, left to right, François Dallaire, Andreea Milasan, Catherine Martel (Photo: Jonathan B. Béland)

High blood cholesterol is an important risk factor for cardiovascular diseases such as atherosclerosis. High-density lipoprotein (HDL) is called “good cholesterol” because it transports cholesterol away from tissues, such as the blood vessel walls, carrying cholesterol through the blood circulation for eventual excretion through the intestines. Unfortunately, the clinical outcomes aiming at increasing levels of circulating HDL have not been as successful as expected READ THE WHOLE STORY »

21 August 2015

Michael Suits, PhD

Department of Chemistry and Biochemistry, Wilfrid Laurier University

Protein structure-function relationships in periodontal disease

Suits_cropped 300wIn the mouth, a wide variety of microorganisms are embedded in biofilms that contribute to periodontal diseases such as gum disease and tooth decay. To understand the contribution of a consortium of periodontal pathogens, including Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, to biofilm formation and dental diseases, Dr Suits’ research group will clone, produce and isolate ~40-50 proteins of interest for structure-function characterization. READ THE WHOLE STORY »

29 January 2015

Brenda Gallie, MD, appointed to the Order of Canada

In December 2014 it was announced that Brenda Gallie, MD, world-renowned ophthalmologist, would receive the distinction of Member of the Order of Canada. The Order of Canada, one of our country’s highest civilian honours, recognizes outstanding achievement, dedication to the community and service to the nation. Dr Gallie was recognized for her contributions to the prevention, diagnosis and treatment of retinoblastoma, a childhood eye cancer.

Dr Gallie received a Banting Research Foundation grant in 1983, shortly after she was appointed assistant professor of ophthalmology at the University of Toronto. READ THE WHOLE STORY »

15 January 2015

Dave Richard identifies key target for malaria prevention and treatment

Dave Richard, PhD, at Université Laval reports that with the funds provided by his 2013 Banting Research Foundation grant his team was able to identify and characterize a protein involved in the generation of specific parts of the malarial parasite cell. This is a critical step in developing vaccines and new medications for malaria. His article on this work will be the laboratory’s first on their malaria cell biology work. READ THE WHOLE STORY »

17 July 2014

Grant Recipients 2014

In 2014, the following early-career researchers received Banting Research Foundation Discovery Awards:

Benoît Arsenault, Université Laval
Impact of a lifestyle modification program on high-density lipoprotein function

Yannick Doyon, Université Laval
In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders

Jennifer Heisz, McMaster University
Examining the dose-response relationship between physical exercise and cognitive function in older adults

Jeffrey Leyton, Université de Sherbrooke
An advanced development in targeted radiation against muscle invasive migrating bladder cancer cells

Ewa Niechwiej-Szwedo, University of Waterloo
The role of binocular vision in the development of fine motor skills

Emanuel Rosonina, York University
Regulation of transcription and splicing factors by sumoylation

Banting Research Foundation
Founded in 1925 by supporters of Frederick Banting,
1923 Nobel laureate for the discovery of insulin


Copyright © 2017 Banting Research Foundation


Log in
Website development by RNA Studio
Powered by WordPress & Atahualpa