17 July 2014

Grant Recipients 2014

In 2014, the following early-career researchers received Banting Research Foundation Discovery Awards:

Benoît Arsenault, Université Laval
Impact of a lifestyle modification program on high-density lipoprotein function

Yannick Doyon, Université Laval
In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders

Jennifer Heisz, McMaster University
Examining the dose-response relationship between physical exercise and cognitive function in older adults

Jeffrey Leyton, Université de Sherbrooke
An advanced development in targeted radiation against muscle invasive migrating bladder cancer cells

Ewa Niechwiej-Szwedo, University of Waterloo
The role of binocular vision in the development of fine motor skills

Emanuel Rosonina, York University
Regulation of transcription and splicing factors by sumoylation

17 July 2014

Benoît Arsenault, PhD

Department of Medicine, Université Laval

Impact of a lifestyle modification program on high-density lipoprotein function

Benoit_microscope_cropped
Plasma levels of high-density lipoprotein (HDL) cholesterol, often referred to as “the good cholesterol”, are inversely associated with cardiovascular disease and type 2 diabetes risk. Several lines of evidence suggest that these associations could be explained by the fact that HDL particles promote macrophage-to-feces reverse cholesterol transport and stimulate insulin secretion from pancreatic beta cells. READ THE WHOLE STORY »

17 July 2014

Yannick Doyon, PhD

Department of Molecular Medicine, Université Laval

In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders

Yannick Doyon and his lab group

Yannick Doyon and his lab group, left to right, Alexandre Raymond-Fleury, Caroline Huard, Yannick Doyon, Jeremy Loehr, Nicolas Lacroix-Pepin


Genetic disorders in children are individually rare but collectively frequent, affecting the lives of approximately 500,000 children in Canada. They often are serious, life threatening or fatal, but because each rare disease affects a relatively small population few treatments have been developed. READ THE WHOLE STORY »

17 July 2014

Jennifer Heisz, PhD

Department of Kinesiology, McMaster University

Examining the dose-response relationship between physical exercise and cognitive function in older adults

Jennifer Heisz talks about her research at a recent Canadian Foundation for Innovation funding announcement (Photo: Ron Scheffler)

Jennifer Heisz talks about her research at a recent Canadian Foundation for Innovation funding announcement (Photo: Ron Scheffler)

Alzheimer’s disease is the most common form of dementia, causing severe cognitive impairment and interfering with daily life. As the population ages, the number of Canadians living with dementia is projected to double within a generation to affect 1.1 million people and cost Canada’s healthcare system in excess of $150 billion. READ THE WHOLE STORY »

17 July 2014

Jeffrey Leyton, PhD

Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke

An advanced development in targeted radiation against muscle invasive migrating bladder cancer cells

Jeffrey Leyton and co-workers

Jeffrey Leyton and co-workers

Bladder cancer affects thousands of Canadians on an annual basis. Unfortunately, bladder cancer remains one of the most difficult cancers to manage. The treatment options currently available to patients with muscle invasive bladder cancer have remained essentially unchanged. For patients with advanced or metastatic disease, bladder cancer is lethal within 2 years. READ THE WHOLE STORY »

17 July 2014

Ewa Niechwiej-Szwedo, PhD

Department of Kinesiology, University of Waterloo

The role of binocular vision in the development of fine motor skills

A young research subject performs motor tasks while her eye and hand movements are recorded. The analysis of kinematic trajectories will provide insight into the development of hand-eye coordination.

A young research subject performs motor tasks while her eye and hand movements are recorded. The analysis of kinematic trajectories will provide insight into the development of hand-eye coordination.

Seeing in depth is essential for guiding purposeful movements, such as reaching and grasping for toys or food, catching a ball or using tools to accomplish complex tasks. Binocular vision provides important cues for 3D depth perception. However, 3-5% of children with amblyopia or strabismus have abnormal binocular vision. READ THE WHOLE STORY »

17 July 2014

Emanuel Rosonina, PhD

Department of Biology, York University

Regulation of transcription and splicing factors by sumoylation

SUMO is a protein modification that plays important roles in regulating many cellular processes. Several proteins that are involved in neurodegenerative disease are modified by SUMO, and abnormal protein modifications by SUMO have been implicated in many types of cancer, indicating that tight regulation of this modification is critical to preventing disease. READ THE WHOLE STORY »

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Founded in 1925 by supporters of Frederick Banting,
1923 Nobel laureate for the discovery of insulin


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