Department of Infectious Diseases, INRS – Institut Armand-Frappier Function of mitochondrial proteases on inflammation and necrosis in influenza virus pathogenesis Every year, people fall ill with the flu, a respiratory disease caused by the influenza virus. Our main tools for fighting deadly flu outbreaks are vaccines and antiviral drugs. But, despite their availability in Canada,…
Salim Islam, PhD
Department of Microbiology and Biotechnology, INRS – Institut Armand-Frappier Bacterial social networking via outer-membrane extrusion: towards an understanding of colonization and persistence Bacteria can colonize both living and non-living surfaces, leading to the development of a microbial community. However, the manner in which different types of bacterial cells interact with each other in such densely-populated…
Julien van Grevenynghe, PhD
Department of Infectious diseases, immunity, cancer and epidemiology, INRS – Institut Armand-Frappier and the Université du Québec Autophagy regulates CD8 T-cell killing activity during chronic HIV-1 infection Autophagy, a natural self-destructive process in cells, eliminates some viruses from cells, and also plays a role in shaping functions of T cells, a primary part of the…
David Chatenet, PhD
Centre INRS–Institut Armand-Frappier Design and synthesis of peptide inhibitors of PqsE as novel antibacterial therapeutics Pseudomonas aeruginosa (Pa), a prevalent opportunistic human pathogen responsible for morbidity and mortality among individuals suffering from cystic fibrosis, is notorious for its high resistance to antibiotic treatments.
Pierre-Yves Lozach, PhD
Centre INRS – Institut Armand-Frappier Bunyavirus entry into mammalian cells Bunyaviridae is a large family of viruses mainly transmitted by arthropods such as mosquitos and ticks. Many bunyaviruses are important pathogens in humans and livestock. Due to their mode of transmission, they are considered emerging agents of diseases. Unfortunately, bunyaviruses are understudied, which has contributed to…
Jonathan Perreault, PhD
INRS – Institut Armand Frappier Regulation in the opportunistic pathogen Burkholderia by the MAEB RNA motif Aside from their role in storing hereditary information, DNA and RNA are now known to have many more functions. Living organisms have a plethora of RNAs that control numerous processes in cells. One such RNA, named MAEB, was recently…
